To reduce the development of drug-resistant bacteria and maintain the effectiveness of TEFLARO and other antibacterial drugs, TEFLARO should be used to. There is minimal potential for drug-drug interactions between TEFLARO and CYP substrates, inhibitors, or inducers; drugs known to undergo active renal . Learn about the proper solution preparation techniques for TEFLARO® before When stored as recommended, the product potency is not affected. Parenteral.
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Limited data in patients receiving higher than recommended Zinforo dosages show similar adverse reactions as observed in the patients receiving recommended dosages. Streptococcus pneumoniae including cases with concurrent bacteremiaStaphylococcus aureus methicillin-susceptible isolates onlyHaemophilus influenzaeKlebsiella pneumoniaeKlebsiella oxytocaand Escherichia coli. There is limited experience in treating patients with diabetic foot infections. If you are a patient, and have any questions, please discuss them with your doctor or healthcare professional.
Zinforo 600 mg powder for concentrate for solution for infusion
The safety assessment in children is based on the safety data from 2 trials in which paediatric patients aged from 2 months to 17 years with cSSTI or CAP received Zinforo. To email a medicine you must sign up and log in.
This site is intended for U. Accessed August 11, Immediate and severe hypersensitivity e.
The effects of ceftaroline fosamil on fertility on humans have not been studied. Appropriate specimens for microbiological examination should be obtained in order to isolate and identify the causative pathogens and to determine their susceptibility to ceftaroline.
Other important toxicologic findings noted in the rat and monkey included histopathologic changes in the bladder and spleen. Animal studies conducted in rat and rabbit do not indicate harmful effects with respect to reproductive toxicity at exposures similar to therapeutic concentrations. Paediatric population As with adults, the interaction potential is expected to be low in paediatrics. Tabulated list of adverse reactions The following adverse reactions have been identified during clinical trials and post-marketing experience with Zinforo.
Streptococcus pneumoniae including cases with concurrent bacteremiaStaphylococcus aureus methicillin-susceptible isolates onlyHaemophilus influenzaeKlebsiella pneumoniaeKlebsiella oxytocaand Escherichia coli.
If you are a patient, and have any questions, please discuss them with your doctor or healthcare professional. Zinforo is indicated for the treatment of the following infections in adults and children from the age of 2 months see sections 4. Marketing authorisation number s 9. Patients experiencing anaemia during or after treatment with Zinforo should be investigated for this possibility.
TEFLARO® (ceftaroline fosamil) Dosing Information
Refers to dosing of adults or adolescents from 12 years and 33 kg with ceftaroline every 8 hours using 2-hour infusions to treat cSSTI see section 4. Diarrhoea, nausea, vomiting, abdominal pain. Seizures have occurred in toxicology studies at times human ceftaroline C max levels see section 5.
The total time interval between starting reconstitution and completing preparation of the intravenous infusion should not exceed 30 minutes.
Arrived in ED with an abscess on the forearm that has worsened from a scrape.
Solution Preparation | TEFLARO® (ceftaroline fosamil)
Ceftaroline fosamil prodrug is converted into the active ceftaroline in plasma by phosphatase enzymes and concentrations of the prodrug are measurable in plasma primarily during intravenous infusion.
By continuing, you are confirming that you have read the Indications and Usage.
Patients who have a history of hypersensitivity to cephalosporins, penicillins or other beta-lactam antibacterials may also be hypersensitive to ceftaroline fosamil. Clinical efficacy has not been established against the following pathogens although in vitro studies suggest that they would be susceptible to ceftaroline in the absence of acquired mechanisms of resistance:. Anaphylaxis see sections 4. Reasons for being admitted to the hospital through the emergency department, Hydrolysis of the beta-lactam ring of ceftaroline occurs to form the microbiologically inactive, open-ring metabolite, ceftaroline M Renal clearance of ceftaroline is approximately equal, or slightly lower than the glomerular filtration rate in the kidney, and in vitro transporter studies indicate that active secretion does not contribute to the renal elimination of ceftaroline.
Please also see full Prescribing Information.
The development of a positive direct antiglobulin test DAGT may occur during treatment with cephalosporins. To view the changes to a medicine you must sign up and log in. Duration of treatment days.
Preparation of Solutions for Adults
Dosage and Administration Dosage and Administration Preparation of Solutions Dosing The minute infusion allows increased flexibility of infusion time See dosing. Infusion volumes for paediatric patients will vary according to the weight of the child. Infected surgical wound For illustrative purposes only. For the full list of excipients, see section 6. Arrived in ED with an abscess due to a suspected spider bite on her left leg.
Pregnancy There are no or limited amount of data from the use of ceftaroline fosamil in pregnant women. Ceftaroline is primarily eliminated by the kidneys. Preferred Contact is required Phone. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy.
Mechanism of action In vitro studies have shown that ceftaroline is bactericidal and able to inhibit bacterial cell wall synthesis in methicillin-resistant Staphylococcus aureus MRSA and penicillin non-susceptible Streptococcus pneumoniae PNSP due to its affinity for the altered penicillin-binding proteins PBPs found in these organisms. Infusion time minutes c. Please confirm that you are a healthcare professional in the United States. This information is intended for use by health professionals.
Susceptibility data should be considered in conjunction with clinical trial data also presented on this website. Show table of contents Hide table of contents 1. There are no or limited amount of data from the use of ceftaroline fosamil in pregnant women.